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The use of high dosages of corticosteroids in the treatment of giant cell arteritis is based on the need to suppress vascular inflammation and decrease the risk of blindnessassociated with giant cell arteritis. However, the actual use of high dosages of corticosteroids in the treatment of giant cell arteritis is not well understood. In order to evaluate the utility of high dosages of corticosteroids for treatment of giant cell arteritis, we performed the first-ever multicenter, double-blind, placebo-controlled phase III trial (Phase IIIa) in patients with giant cell arteritis treated with low daily doses of 2% corticosteroids for 6–12 months. In order to assess the potential of low daily doses of 2% corticosteroids for the treatment of giant cell arteritis, patients were allocated to two groups in order to identify the response to treatment with low daily dosages of 2% corticosteroids vs. continuous daily 5% doses of corticosteroids for 6 months. Twenty patients were treated in each group in a consecutive 3-month period. During Phase IIIa, patients were randomly assigned to a single-blind, double-blind placebo-controlled, parallel group design. Patients in the two treatment groups received a single dose of 2% corticosteroids (2 mg), followed by a 5% dose of corticosteroids (5 mg) in the evening every two weeks (0, 7, 14, 28 and 45 days). During Phase IIIb, patients were randomly assigned to an interval intervention group to receive placebo every day for 6 weeks, or a dose of corticosteroids in the morning by oral administration (4 mg) and a 5% dose of corticosteroids (5 mg) in the evening every two weeks (3, 7, 14, 28 and 45 days). No severe adverse events were reported during Phase IIIb. No significant change in patient-reported visual acuity, visual field, patient-reported functional outcomes, or clinical laboratory variables was observed in the two treatment groups, although significant changes in clinical laboratory variables were observed in both treatment groups (see Figure). Therefore, the findings suggest that 2% to 3.4% daily doses of 2% corticosteroids are effective in treating giant cell arteritis. Citation: Wang L, Yu M, Chang J, Sun A, He YQ, Yee D, et al. (2017) Low Daily Doses of 2% Corticosteroids Reduce Giant Cell Artery Disease in Patients with Giant Cell Artery Disease. PLoS ONE 12(10): e0176958. https://doi.org/10.1371/ Similar articles:
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